Contact: Li Tel :027-87738627 QQ: 2387256661 Chinese name: proanthocyanidins 1 Introduction proanthocyanidins, the English name is Proantho Cyanidins (PC) [1], the English aliases: 2 - (3,4-Dihydroxyphenyl) -2 - (( 2 - (3,4-dihydroxyphenyl) -3,4-dihydro-5 ,7-dihydroxy-2H-1-benzopyran-3-yl) oxy) -3,4-dihydro-2H-1-benzopyran-3, 4 ,5,7-tetrol; [2] 2 - (3,4-dihydroxyphenyl) -2 - {[2 - (3,4-dihydroxyphenyl) -5,7-dihydroxy-3 ,4-dihydro-2H-chromen- 3-yl] oxy} -3,4-dihydro-2H-chromene-3 ,4,5,7-tetrol, there is a special molecular structure of bioflavonoids, is extracted from the leaves of blueberry proanthocyanidins resistant hepatitis C virus is internationally recognized as the clear the body of free radicals of the most effective natural antioxidants. Generally reddish brown powder, gas micro, astringent taste, soluble in water and most organic solvents. Usually grape seed extract or pine bark extract French coast. Proanthocyanidins (grape seed extract) is a new highly effective antioxidant, is by far the most potent discovered radical scavenger, has a very strong activity in vivo. Experiments show that anti-free radical oxidation OPC is 50 times more vitamin E and 20 times the vitamin C and rapidly absorbed completely, oral 20 minutes to reach the highest blood levels, metabolic half-life of up to 7 hours. 2 structure in the structure, proanthocyanidins is a combination of different amounts of catechins (catechin) or epicatechin (epicatechin) together. The simplest procyanidins catechin, epicatechin, catechin or epicatechin dimer formation, in addition to trimers, tetramers, etc. until ten mer. Degree of polymerization according to the size, usually referred to as two to pentameric oligomeric proanthocyanidins (referred OPC), the above referred to pentameric procyanidin high polymer [1] (referred to as PPC). 3 major blood circulation in Europe, in order to improve blood circulation, treatment of diabetic retinopathy, reducing edema and inhibition varicose veins, proanthocyanidins been used in clinical treatment for decades. Proanthocyanidins can strengthen capillaries, arteries and veins, and therefore, it has the effect of swelling and stasis. Reduce capillary permeability resistance and improved so that the cells more easily absorb nutrients and eliminate waste. Transport of nutrients and waste which is transported out of the blood circulatory system function. The heart is responsible for pumping the blood pressure; arteries and veins transport blood; and is responsible for transporting nutrients to the cells, and the waste is shipped out of the capillaries. Proanthocyanidins can remove water-soluble and fat-soluble membrane radicals Thus, inhibition of certain enzymes to release the capillary wall injury process. Proanthocyanidins tonic effect can be observed in a very short time. Professor, University of Bordeaux, France HenriChoussat did a test, trial by 47 people, ranging in age from 37 years to 85 years, each taking 100 mg of anthocyanins. 27 hours after the discovery, capillary resistance reduced by 40%. Eye protection signs of diabetic retinopathy is diabetes, which is caused by bleeding eye micro capillaries, is a common cause of adult blind. France allows proanthocyanidins treatment of the disease for many years. This approach significantly reduces capillary bleeding eyes and improve vision. Proanthocyanidins have also been used to prevent complications after cataract surgery in diabetic patients. In 1998, the experts chose the eye of many eye injuries who did not do the test, examine whether proanthocyanidins can relieve night blindness. Participants were divided into two groups, one group of drivers to drive at night, a group of computer screens all day and people as partners. After four weeks, and then check their ability to withstand the blind, 98% of the test persons had improved. Eliminate edema edema is blood in the water, electrolytes and other human tissue infiltrated the cause, it is usually swelling of the injured area. Sitting too long healthy people have edema, edema there before menstruation, sports injuries often cause edema, there may be some swelling after surgery, some diseases can also cause edema. Studies have shown that once-daily anthocyanins can significantly alleviate edema. University of Bordeaux, France, has done clinical trials to investigate the average age was 60 years, 40 patients have edema disease. Participants were divided into two groups, patients taking 300 mg within 60 days of anthocyanins per day to alleviate all symptoms. 30 days, 26% of patients with swelling disappeared. 60 days, 63% of the test subject's leg edema cured. Moisturize the skin for the youth of Europe called proanthocyanidins nutrition, skin vitamins, oral cosmetics. Because it can restore the vitality of collagen, making skin smooth and elastic. Collagen is the basic constituent of the skin, so that our body and is a rubbery material as a whole. Vitamin C is necessary for collagen synthesis and biochemical nutrition. Proanthocyanidins make more effective vitamin C, which means that the vitamin C can be more easily to complete all its features (including collagen production). Proanthocyanidins connected collagen, can prevent the destruction of collagen harm those enzymes. Proanthocyanidins not only helps collagen fibers form a crosslinked structure, and can help restore damage caused by excessive crosslinking of injuries caused by free radicals. Excessive crosslinking causes suffocation and hardening of connective tissue, so that the skin wrinkles and premature aging. Anthocyanins also protect the body from sun damage and promote a cure for psoriasis and Shou spots. Proanthocyanidins is also an excellent additive for topical application of skin cream. Cholesterol Cholesterol is an essential component of cell membranes, produce hormones and promote the transport of fatty acids is concerned, it has played a key role. However, too much cholesterol is a potential bad omen. Combination of proanthocyanidins and vitamin C can break down cholesterol, bile salts become, and then out of the body. Proanthocyanidins accelerate the decomposition of harmful cholesterol and exclusion. Here, collaborative relationship between vitamin C and anthocyanins once again been confirmed. Cardioprotective agent proanthocyanidins not only help restore skin elasticity, but also help the joints, arteries and other tissues (such as heart) to maintain normal function. Blood flow is responsible for the vascular system, the blood to all tissues and cells. So, whether it is from a long-term and short-term effect, proanthocyanidins are found to date, the best cardioprotective agent. Proanthocyanidins also inhibit histamine, which reduces inflammation, helps arteries that lead to cardiovascular disease resist impact mutagenic factors. Although the French eat a high-fat foods are usually far more than the Americans, but the French people die of heart disease than Americans, much less the proportion of French people love to drink famous meal will usually drink. The number of coronary heart disease in France gentleman drink than not drink population by 30% to 40%, this is because the French red wine contains proanthocyanidins. Irritation proanthocyanidins not help slow cardiovascular inflammation, and may also help in the treatment of many diseases such as allergies, asthma, bronchitis, hay fever, rheumatoid arteritis, sports injuries, pressure ulcers. When inflammation of the body to release a compound called histamine, which can be induced by a variety of symptoms of these diseases. Anthocyanins inhibit the histamine required to produce the enzyme, preventing the formation of histamine, thereby reducing inflammation. Procyanidins are inhibitors of histamine famous, but it does not hinder other enzymes. We suffered too much body of chemicals and pollutants from food, drinking water, air, plants and animals (such as pollen), the result of allergies has become a very common disease. Capacity about anti-allergy and anti-inflammatory proanthocyanidins, and many papers have documented. Athletes very appreciated anthocyanins, proanthocyanidins because the joints flexible and can be repaired within the connective tissue collagen, and reducing edema. There are reports of many people proanthocyanidins improve arthritis. Varicose veins of disorders may include pain, itching, burns, fatigue. Severe varicose veins can cause heart disease, stroke, thrombophlebitis, pulmonary embolism, and so on. Dr. Haake has done clinical studies in Hamburg, Germany, found that proanthocyanidins beneficial to patients with varicose veins. Patients in this study had 110 people, including 41 who have leg spasms. Daily oral administration of 90 mg of anthocyanins patients, 77% of the trials were a significant improvement. In addition, 93% of patients with symptoms of leg cramps disappeared. Brain function can help improve memory proanthocyanidins, slow aging and the risk of stroke. Even after a stroke occurs, proanthocyanidins can help improve memory and brain function, this fact has been proven in clinical studies. For example, children's hyperactivity disease (or ADHD), often called Ritilan with western medicine treatment. This medicine has side effects hinder the growth of the child, the patient may it produce dependence, once stopped taking patients will have increased appetite, depression and lethargy and other symptoms. Some reports suggested that alternative Ritilan both effective and safe natural supplements with proanthocyanidins. Improve hypoxic hypoxia refers to the long-term lack of oxygen, which the body has irreparable harm. Elderly hypoxia may cause mental and physical problems, such as suffering from Alzheimer (Eerchamo) disease. Older people, the blood circulation is often not very good. Proanthocyanidin free radicals, inhibiting the rupture of capillaries and the destruction of surrounding tissue. Proanthocyanidins also improved the capillary state, enhancing blood flow to the brain circulation and therefore, more oxygen is obtained brain. Premenstrual syndrome clinical trial results show that the former can reduce the proanthocyanidins women afflicted by (tension) syndrome. Because the hormones out of balance, there will be many kinds of psychological and physical symptoms. Fluid retention affect normal blood flow as a result, brain, ovary and uterus can not get enough oxygen. Low blood sugar may also be a factor in inducing premenstrual syndrome. This disease may manifest as any one or all of the following symptoms: breast swelling and tenderness, back pain, abdominal bulge, muscle spasms, personality changes (such as anger, rage, and even tried to commit suicide), depression, fatigue , syncope, insomnia, joint pain, headache, urine retention. In a study by the PMS, there are 165 women taking oral 200 mg of proanthocyanidins per day. Two months later, 60% of women physical illness disappeared. Four months later, 80 percent of women physical symptoms gone, half the women in the psychological aspects of the disease does not exist. There are a lot of proanthocyanidins nourishing, wholesome research reports, which include the following (but not limited to) these areas: improved liver function and reduce the risk of phlebitis and cancer, multiple sclerosis, and improved prevention cataracts. 4 health functions 1, through three ways to protect the body's circulatory system: remove oxygen free radicals present in the blood; help the body to prevent the generation of oxygen free radicals; enhance the integrity of the vessel wall. 2, the inhibitory effect of collagenase and elastase degradation of connective tissue, which helps maintain the skin's elasticity, exert anti-aging skin effect. 3, can enhance retinal capillaries and limb peripheral capillary microcirculation. 4, by maintaining healthy blood vessels and improve microcirculation, so that all organs and tissues to obtain more adequate blood supply. 5, can enhance immune function, improve the performance of proanthocyanidins alcohol fed mice and mice infected with retroviruses cytokine immune response 2. 6, proanthocyanidins also enhance the efficacy of vitamin C, vitamin C, extend in the human body occurs efficacy time. 7, proanthocyanidins very good solubility in water, after the oral absorption into the body fast onset and duration of action lasting. 8, as a health food, security is very important. The results of animal experiments and a variety of systems research proves that proanthocyanidins non-toxic, non-mutagenic, non-carcinogenic, non-teratogenic, non-allergenic, so proanthocyanidins is safe. Professor Masquelier 5 safety performance, and many scientists use proanthocyanidins, has done research for many years in various clinical, laboratory, toxicity and pharmacokinetics. Extensive testing proved that proanthocyanidins are non-toxic, carcinogenic, no antigenicity, without fetal malformations tonic. Professor Masquelier noted that he proanthocyanidins treatment and prevention forty years, had never seen a direct or indirect toxicity.